Medtronic
Medtronic Guardian 4
$2478.3Cheaper
Released 2023-04
Best Continuous Glucose Monitors · head-to-head
Medtronic Guardian 4 vs Senseonics Eversense E3
A sourced, side-by-side comparison. Medtronic Guardian 4 is cheaper at $2478.3. Every spec and price links to its source.
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Senseonics
Senseonics Eversense E3
$3309.69
Released 2022-02
Which is better: the Medtronic Guardian 4 or Senseonics Eversense E3?
On the specs we track, they're closely matched. The Medtronic Guardian 4 is the cheaper at $2478.3.
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Full spec sheet
✓ marks the stronger figure where "more" — or "less", for price and weight — is unambiguously better.
| Spec | Medtronic Guardian 4 | Senseonics Eversense E3 |
|---|---|---|
| US price | $2478.3 | $3309.69 |
| Brand | Medtronic | Senseonics |
| Released | 2023-04 | 2022-02 |
| Wear duration days | 7 | 180 |
| Warmup time hours | 2 | 24 |
| Reading interval min | 5 | 5 |
| Water resistance | Splash-resistant only; not rated for submersion | Sensor is water-resistant once implanted; the external transmitter is removable for bathing/showering |
| App platform | iOS & Android (Guardian Connect app); also displays on the MiniMed 780G pump | iOS & Android (Eversense NOW app) |
| Prescription required | Yes | Yes |
| Mard accuracy pct | 10.6 | 8.5 |
| Sensor size | 1.50 x 2.60 x 2.00 in | approx. 0.72 x 0.14 in (18.3 x 3.5 mm) implantable sensor |
Sources — Medtronic Guardian 4: consumerguide.diabetes.org (verified 2026-08-01). Senseonics Eversense E3: diabetesnet.com (verified 2026-08-01).
What's the difference between the Medtronic Guardian 4 and Senseonics Eversense E3?
Where the two actually differ on the specs we track (6 of 8). Matching specs are omitted.
- Wear duration days: Medtronic Guardian 4 7 vs Senseonics Eversense E3 180
- Warmup time hours: Medtronic Guardian 4 2 vs Senseonics Eversense E3 24
- Water resistance: Medtronic Guardian 4 Splash-resistant only; not rated for submersion vs Senseonics Eversense E3 Sensor is water-resistant once implanted; the external transmitter is removable for bathing/showering
- App platform: Medtronic Guardian 4 iOS & Android (Guardian Connect app); also displays on the MiniMed 780G pump vs Senseonics Eversense E3 iOS & Android (Eversense NOW app)
- Mard accuracy pct: Medtronic Guardian 4 10.6 vs Senseonics Eversense E3 8.5
- Sensor size: Medtronic Guardian 4 1.50 x 2.60 x 2.00 in vs Senseonics Eversense E3 approx. 0.72 x 0.14 in (18.3 x 3.5 mm) implantable sensor